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Ngadino,
- Larvicidal Activity of Ethanol Leaf Extract of Pinus merkusii on Aedes aegypti larvae
Authors
1 Department of Pharmacology, Airlangga University, Surabaya, ID
2 Study Program of Environmental Health, Polytechnic of Health, Surabaya, ID
3 Hang Tuah University, Surabaya, ID
Source
Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1011-1014Abstract
The mosquito species, Aedes aegypti L. is a vector of major diseases such as dengue haemorrhagic fever, chikungunya and yellow fever. Therefore, it is necessary to find new bioinsectiside which is expected to have larvicidal effects. This study investigates ethanol leaf extracts of Pinus merkusii for efficacy against Aedes aegypti larvae. This experiment using a completely randomized design with 8 treatment groups. Each group contained five times repetition using 20 third instar larvae of Aedes aegypti with concentrations of Pinus merkusii leaf extract are 0, 10, 20, 40. 80, 160, 320, 640 ppm. Larval mortality was observed for 24 h, LC50 and LC90 were analyzed using Probit analysis. Ethanol leaf extract of Pinus merkusii showed highest larvae mortality against the larvae of Aedes aegypti with LC50 = 145.7 ppm; LC90 = 379.4 ppm after 12 h, and LC50 = 86.3 ppm; LC90 = 173.6 ppm after 24 h. These findings suggest that ethanol leaf extracts from Pinus merkusii have larvicidal activity that can be exploited in development of new bioinsecticides.Keywords
Extract Pinus merkusii Leaf, Larvicidal, Aedes aegypti.
- Evaluation of Antimycobacterial Activity of Curcuma xanthorrhiza Ethanolic Extract against Mycobacterium tuberculosis H37Rv in vitro
Authors
1 Study Program of Environmental Health, Polytechnic of Health, Surabaya, ID
2 Department of Pharmacology, Wijaya Kusuma University, Surabaya, ID
3 Department of Pharmacology, Airlangga University, Surabaya, ID
Source
Veterinary World, Vol 11, No 3 (2018), Pagination: 368-372Abstract
Aim: The aim of this study was to evaluate the antimycobacterial activity of the Curcuma xanthorrhiza ethanolic extract in vitro.
Materials and Methods: Ethanolic extract of C. xanthorrhiza was set by maceration method. The broth microdilution and disc diffusion method were used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), respectively, of C. xanthorrhiza ethanol extract on strain Mycobacterium tuberculosis H37Rv.
Results: C. xanthorrhiza ethanol extract was found to have the antimycobacterial effects with a MIC value of 1600 μg/ml while MBC value of 3200 μg/ml for M. tuberculosis H37Rv.
Conclusion: From these findings , it can be concluded that C. xanthorrhiza ethanol extract have an antibacterial activity against Mycobacterium tuberculosis H37Rv in vitro and its potency elevated by increasing the C. xanthorrhiza ethanol extract concentration.
Keywords
Antimycobacterial, Curcuma xanthorrhiza, Minimal Bactericidal Concentration, Minimal Inhibitory Concentration.Full Text
